Via Scientific Games' OGS platform, Gaming Realms' Slingo Portfolio is now live with Goldbet and Sisal Group, while it will launch with Lottomatic later in February.
Gaming Realms has been showing steady growth in recent years and already has a number of high-profile partners such as Entain, 888 Holdings and Kindred Group, also working with Caesars Interactive among others in the US.
Michael Buckley, Gaming Realms executive chairman, said: "Goldbet, Sisal Group and Lottomatica are all tier one Italian gaming operators and have been innovating the world of gaming internationally for many years.
"We are delighted to be making this first step into the Italian market with them as our partners.
"The company has complied with all the necessary guidelines and regulations to enter this new, regulated market and we now look forward to bringing our Slingo content to a new audience and exploring further distribution opportunities in Italy, as we remain focused on increasing our international presence."
Last week saw Gaming Realms' share price rise to a high of £37.30 ($51.04), having sat at £30.40 at the end of the previous week.
Early this week, however, that value has fallen slightly to £33.60.
