The casino will become the first Swiss casino operator to use Oryx's portfolio, with other deals set to be announced.
Luzern’s online brand mycasino.ch will be used to launch Oryx content to Swiss consumers.
Oryx has also recently reached agreements in Croatia, Romania, Spain, Portugal and America.
Matevž Mazij, MD of Oryx Gaming, said: “Switzerland is a very exciting young market and we are pleased to finally take our content live with Grand Casino Luzern.
“This marks the beginning of our venture in Switzerland; we look forward to further establishing our presence in the country and providing players with the premium content we have to offer."
Wolfgang Bliem, CEO at Grand Casino Luzern, added: “Following a very smooth integration process we are thrilled to now offer GAMOMAT’s proven content to our player base.
“Our business continues to go from strength to strength and our offering has been further improved by our partnership with Oryx.”