Oddsworks specialises in delivering gaming content and interactive technology to regulated and real-money gaming markets.
The partnership is expected to come into effect this year, in Michigan, New Jersey, Pennsylvania and West Virginia.
Oddsworks President Larry DeMar said: "We are pleased to be partnering to provide our unique, proven game content via the versatile Betguard platform to BetMGM.
"We look forward to working with BetMGM and to grow our respective operations. BetMGM is a hugely respected and admired brand. They are also a great business partner."
Additionally, BetMGM has announced the appointment of actor Jerry Ferrara as celebrity brand ambassador and podcast host.
Ferrara will co-host BetMGM’s weekly sports podcast, Unleashed, participate in fan events and feature in BetMGM promotional campaigns.
Ferrara said: "As a diehard sports fan, I couldn't be more excited about legalised sports betting and having the opportunity to partner with an industry leader like BetMGM.
"It's an honor to be the first BetMGM ambassador to co-host Unleashed and I'm excited to share my passion and knowledge with fellow sports fans."
BetMGM CRO Matt Prevost added: "Jerry Ferrara is a talented actor and a passionate sports fan. Together we'll create fun, unique content for our podcast and other BetMGM-related opportunities that we believe sports fans will love."
Recently, MGM Resorts International reported a $1bn year-on-year revenue rise for Q2, attributable to the success of its Las Vegas operations.
