While reporting its Q2 results, the operator confirmed the executive, who has worked in the gaming industry for over 30 years, will depart his role and be succeeded by Jay Snowden, COO since 2014 and President since 2017.
Wilmott joined Penn National in 2008 and was named CEO in 2013.
He said: "I am very grateful for the opportunity to have led Penn National through a transformational period in the company’s history, including the acquisition of Pinnacle Entertainment, the creation of the industry’s first gaming REIT and other initiatives that have driven growth, created shareholder value and positioned the company for future success."
Snowden said: "We are entering a very dynamic time for our company and I couldn’t be more excited, honoured and humbled to lead this amazing company into the future."
In its Q2 trading update, Penn National reported a 61% year-on-year increase in revenue to $1.32bn, although this was chiefly thanks to its acquisition of Pinnacle Entertainment.
The casino company also recently announced new partnerships with supplier Kambi and operators DraftKings, PointsBet, TheScore and The Stars Group.
Kambi CCO Max Meltzer will be speaking exclusively to Gambling Insider about the Penn National deal.