The sportsbook will be part of Mohegan Sun Casino Las Vegas' 60,000 square foot gaming venue.
Betfred created its USA Sports arm in 2019, with this partnership marking the company's fourth US sportsbook; its others reside in Iowa, Colorado and Pennsylvania.
Mohegan Sun Casino Las Vegas' eight-month renovation is currently underway; it is scheduled to open later this year.
Aviram Alroy, VP of interactive gaming at MGE, said: "Our affiliation will introduce new and attractive competition to the Las Vegas market.
"Betfred will create a seamless and best-in-class experience on our gaming floor, which will cater to both domestic and international visitors."
Betfred Group COO Mark Stebbings said: "Given our collaboration with two outstanding operators in Mohegan Gaming & Entertainment and Virgin Hotels Las Vegas, we are confident our first foray into the Las Vegas Sportsbook market will be a great success.
"Through our shared expertise, we will be offering a top-class service for sports bettors in the entertainment capital of the world."
