Musgrove was welcomed by Sycuan as the organisation's first MLB ambassador in 2022.
As part of the deal, Musgrove will continue to appear in social media posts, take part in community activities and make appearances in the casino.
Rob Cinelli, General Manager at Sycuan Casino Resort, said: "We are thrilled to announce the re-signing of MLB All-Star pitcher Joe Musgrove as our brand endorser for the next two years.
"Joe not only is an incredible athlete, but his deep commitment to the San Diego community aligns perfectly with our brand values. He quickly has become a beloved member of the Sycuan family and we look forward to seeing the positive impact he will continue to make both on and off the field."
Musgrove said: "After a successful first year, I couldn't be more excited to continue my partnership with Sycuan Casino Resort.
"From meeting and interacting with guests to creating my menu items like the one-of-a-kind Musgrove Dog, representing Sycuan has been an absolute blast.“It's been wonderful to work with a brand that demonstrates how much they care about our community in everything that they do. I look forward to continuing our partnership and all of the great things to come."
The 40th minute of every contest will also be broadcast by Sycuan.