The 105,000ft2 space is the largest single-floor office in Boston, more than double the size of DraftKings’ previous home.
The operator currently has more than 700 employees on the books and the new office will help DraftKings focus more on in-house content creation.
Professional production and podcast studios will be on site to bolster those efforts, as well as green rooms.
Since being founded in 2012, DraftKings has established offices in locations across the US, including California, Florida, Nevada, New Jersey and New York.
Attending the opening ceremony were company Co-Founders Jason Robins, Paul Liberman and Matt Kalish, Massachusetts Governor Charlie Baker and Lieutenant Governor Karyn Polito.
Robins, DraftKings CEO and Co-Founder, said: "Our new headquarters will foster innovation while providing a true home field advantage as we work toward our goal of being the ultimate sports entertainment destination for fans."
Governor Baker said: "We are glad to support an environment that encourages the expansion of Massachusetts-based tech companies like this one."