The bookmaker has launched the partnership with England Men’s, Women’s and Wheelchair teams.
Betfred has been the title sponsor of the Super League since 2017, with its Rugby League deals also including the Championship, League 1 and the Women’s Super League.
The Betfred logo will appear on the back of all three England team jerseys throughout the tournament, which is scheduled to take place in England across October and November 2021.
"Following our very successful association with Rugby League at all levels in recent years, Betfred are delighted to become an official partner of the England Men’s, Women’s and Wheelchair teams for the Rugby League World Cup in 2021," said Betfred owner Fred Done.
Host cities include London, Leeds, and Sheffield, with Newcastle’s St James’ Park the venue for the Men’s opener between England and Samoa.
Mark Foster, the Rugby Football League’s chief commercial officer, added: "Betfred have been outstanding sponsors for Rugby League for the last four years and it’s fantastic that they will now extend that support to our England teams in 2021.
"It’s such an exciting time for our Men’s, Women’s and Wheelchair teams as they prepare to play World Cups on home soil."