Governor Chris Sununu signed legislation in July 2019 authorising the New Hampshire Lottery to conduct sports betting, allowing as many as 10 physical sportsbook locations, along with mobile sports betting.
DraftKings was selected for the agreement following a competitive bidding process.
Through the contract, the New Hampshire Lottery will receive 50% of gaming revenue from sports betting sales, with mobile sports betting expected to launch in January 2020.
New Hampshire sports betting legislation allows individual communities to vote on whether to allow retail sports betting locations in their areas.
The cities of Berlin, Claremont, Franklin, Laconia, Manchester and Somersworth have all voted in favour of sportsbook locations so far.
Matt Kalish, Chief Revenue Officer and Co-founder at DraftKings, said: "We look forward to collaborating further with the New Hampshire Lottery to bring the DraftKings experience to sports fans in the Granite State.
"Our best-in-class mobile sportsbook and several retail locations throughout the state are sure to be a hit with all types of customers, as legalised sports betting continues to expand across the country."
