Scientific Games will provide its online gaming platform and games content portfolio for DraftKings in New Jersey.
DraftKings provides daily fantasy sports (DFS) in the US and, since the overturning of PASPA, has become a key player in the US sports betting market.
DraftKings agreed a deal back in December to purchase sports betting supplier SBTech, so this move with Scientific Games will purely be for its online gaming platform.
The launch gives DraftKings players access to the company's library of titles available in the US, including titles and third-party games from partner studios through SG Digital's Open Gaming System aggregation platform.
The operator did also previously sign a live casino agreement with Evolution Gaming in New Jersey.
Dylan Slaney, SVP Casino for SG Digital, said: "New Jersey is booming right now and DraftKings has a strong foothold in the market.
"Throw our content and platform into the mix and you've got a powerful combination of two market leaders that will bring players the best online gaming experiences available today."