Broncos vs. Chiefs Odds, Picks & Predictions: Best Bets for Monday Night Football

Patrick Mahomes is back after recovering from ACL & MCL tears. His counterpart, Bo Nix, also returns after fracturing his ankle in last year’s playoffs.

Broncos vs. Chiefs Odds at Kalshi

Here are Broncos vs. Chiefs odds at Kalshi:

The Chiefs also expect to have WR Xavier Worthy (shoulder) in the starting lineup tonight.

Best Bet Broncos vs. Chiefs: Against the Spread

Broncos +2.5 (-104)

Denver swept the season series with Kansas City last season. The Broncos also supplanted the Chiefs as AFC West champion, ending a nine-year run of divisional supremacy for Kansas City.

The Chiefs added Super Bowl MVP Kenneth Walker III to the fold in the offseason. Tight end Travis Kelce also returned for his 14th season.

Denver’s biggest offseason acquisition came in landing former Miami WR Jaylen Waddle. Waddle and WR1 Courtland Sutton give Nix two strong targets in the passing attack. Expect the Broncos to lean on the aerial attack against a new-look secondary for the Broncos. Trent McDuffie and Jaylen Watson both left to join the Rams.

Rookie CB Mansoor Delane (LSU) will be tested in his professional debut tonight, as Denver head coach Sean Payton favors a pass-first attack. Nix threw the ball 46 times before getting hurt in the playoff loss to Buffalo.

Kansas City will look to establish the running game with Walker to take some pressure off Mahomes. Kelce, Worthy, and WR1 Rashee Rice can expect to see their fair share of targets tonight. The Broncos counter with Patrick Surtain III, who is widely recognized as the NFL’s best cornerback. Expect Surtain to shadow Rice, who caught six balls against the Broncos in his only appearance against them last season.

There is one significant injury heading into MNF. The Chiefs will be without starting left tackle Josh Simmons (back) tonight. Undrafted rookie Khalil Benson will be forced into action after he struggled some with pass protection during training camp. That’s a scary blind-side proposition for Mahomes as he works his way back from injury.

Denver displayed its penchant for winning close games last season. The Broncos were 11-2 in games decided by eight points or less, including both wins against Kansas City.

Pick: Broncos +2.5

Best Player Prop for Broncos vs. Chiefs

Bo Nix 35+ Passing Attempts (+104)

For all of the reasons detailed above, we like Nix to have at least 35 passing attempts. Kansas City’s revamped secondary will likely take some time to gel, and Payton’s offensive attack will try to exploit it.

Nix attempted 37 and 38 passes, respectively, in the wins over Kansas City last season. Tonight should be no different.

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Kris Johnson

Deputy Editor

Kris Johnson is a graduate of Middlebury College. He has spent most of his life working in sports, primarily writing about them.

Before starting his most recent position as Deputy Editor in the summer of 2025, Johnson spent nearly four years with Catena Media as a senior writer.

His career began at a Gannett newspaper in Saratoga Springs, N.Y., where Johnson oversaw the production of a daily horse racing betting supplement called “The Pink Sheet” during Saratoga’s famed summer thoroughbred meet.

Johnson then worked for the Detroit Red Wings as director of media relations for the NHL’s top minor league affiliate in upstate New York.

He then spent four years with MMI/IMG in Charlotte, N.C., where he ultimately served as publicist for NASCAR champion Dale Jarrett on behalf of sponsor UPS.

His work has appeared in Sports Business Daily, Sports Business Journal, The Sporting News, and NASCAR Illustrated. Johnson received the Catlin Journalism Award of Excellence on two occasions.

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