It will instead turn its attention to the Kanto region, which includes Japan’s capital city, Tokyo.
In June, Wynn was one of seven companies involved with bidding for the right to establish and operate an integrated resort in Osaka.
It took part in the request-for-concept (RFC) period and consulted with city officials and residents on the possibility of building an integrated resort.
Wynn is the third major international operator publicly linked with Osaka’s RFC process that passed on the opportunity.
Las Vegas Sands said it would focus on Tokyo and Yokohama while Melco Resorts and Entertainment said it would adopt a “Yokohama First” policy.
However, MGM Resorts International remains committed to Osaka. In August, MGM COO Bill Hornbuckle told Gambling Insider: "Japan is the largest untapped market in the world that we think can be regulated properly and a place we might be able to get to. It represents the economics of something like Singapore.
“There will be three coveted licenses. Each one of them will have an audience of about 30 million if they are spread out correctly. So we’re all in. We’ve taken an Osaka-first position and we want to build something extremely special."