Speaking at a symposium held in the city, Tanasijevich said the resort should become an iconic part of the city skyline and a major contributor to Yokohama's economy.
He expressed a desire to emulate the success of the Marina Bay Sands resort in Singapore, while giving the Yokahama site its own distinct style, which "compliments and integrates with existing infrastructure."
Tanasijevich said: "I want to create entertainment not yet seen before. I want to make Yokohama a place I want to visit over and over again.
"I want a Japanese partner and to develop a business understanding of what is needed in the area. I hope to be a welcome presence and enjoy growth along with Japanese business."
Earlier this year, Las Vegas Sands and Melco Resorts both abandoned plans for casinos in Osaka after announcing a Yokohama-first stance.
Las Vegas Sands Q3 revenue was $3.3bn, a decrease of 4% year-on-year.
Despite the drop, Sheldon Adelson, Las Vegas Sands Chairman and CEO, said: "We remain enthusiastic about our future growth opportunities in Asia."
