Kobrine will remain in his position until a successor is in place and the 888 board will now begin the search for the CFO’s successor.
Kobrine joined 888 in 2004 ahead of the group's IPO and was appointed CFO in June 2005.
He said: "I would like to take this opportunity to thank the fantastic team at 888 with whom I have had the pleasure and honour of working with over the last 15 years.
"I am incredibly proud of what we have achieved together throughout my time with the business."
Brian Mattingley, 888 Chairman, said: "Aviad has made a truly outstanding contribution to 888.
“Aviad has been an integral part of the leadership team throughout a transformational period for the company."
Itai Pazner, 888 CEO, said: "On behalf of the entire 888 team I would like to thank Aviad for his significant contribution to the group.
"I would also like to extend my personal gratitude to Aviad for his support and friendship over the years."