Research by bestcasinosites.net shows the 334 casinos in Nevada lost an average of $33.3m revenue each day, as venues were closed from March until June, meaning the state ranked number one for the most revenue lost.
The study ranks the 58 destinations with the highest revenue from casinos worldwide, to uncover which destination has been the worst hit during the pandemic, in terms of lost revenue.
The second-highest affected destination was the pachinko market in Japan, losing a total of $8bn, an average of $22.2m lost for everyday properties were closed.
Macau was ranked in ninth place, with losses totalling $2.73bn, equating to $7.5m daily for its 41 casinos, while Singapore was third, Canada fourth and Australia fifth.
France was ranked as the highest impacted in Europe, sitting 10th overall, with total losses of $2.66bn.
The $1.84bn losses for casinos in Great Britain put the market in 15th place, with an average daily loss of just more than $5m for the 150 casinos, which remain closed until at least 15 August.
However, the US market was the hardest hit overall, with New Jersey, Pennsylvania and New York also featuring in the top 10.
While land-based venues have been significantly hit by the pandemic, industry has shifted to online alternatives as a result.