The positions are being cut due to MGM Resorts’ corporate restructuring program, as the company looks to reduce its labour costs by $100m.
MGM Resorts executives revealed the cost cutting had the potential to lead to an additional $300m in cash flow by 2021.
CFO Dan D’Arrigo and Senior Vice President Alan Feldman have both announced their departure under a buy-out program, transitioning into an advisory role.
It has yet to be confirmed how many more positions will be cut.
MGM Resorts shares closed at $27.75 in trading on the New York Stock Exchange on Thursday, falling 12% since August.
Murren said: “We need to create a company that is streamlined, nimble and empowers leaders. I want to unleash innovation and support dynamic new ideas; we need a new way of operating.”