Both of the new agreements are with WSI USS, LLC, a wholly owned subsidiary of Wynn Resorts.
Indiana has already regulated sports betting but the vertical is contingent upon a statewide referendum in Colorado, scheduled for 5 November.
Full House Resorts President and CEO Daniel Lee said: "We are excited to partner with Wynn Resorts, allowing them to conduct mobile sports wagering throughout Indiana and Colorado.
"Wynn Resorts is renowned for its unparalleled focus on guest service and as the premier operator in the gaming industry.
"We are thrilled to see them bring their unique vision to the online space."
